Contents: Treat, Bootzin, Baker, Preface. Kraut, Insel, Cuthbert, Fowles, Steinmetz, Foreword. Part I: History and Epistemology of Psychological Clinical Science. Bootzin, Psychological Clinical Science: Why and How We Got to Where We Are. O’Donohue, Lilienfeld, The Epistemological and Ethical Dimension of Clinical Science. Miller, Engels, Herrington, The Seduction of Clinical Science in Psychology: How Psychological and Biological Convergence Can and Can't Work. Part II: Application of Clinical Science to Topics of Applied Significance. Liverant, Stoddard, Meuret, Barlow, Clinical Science and the Revolution in Psychological Treatment: The Example of Anxiety Disorders. Mystkowski, Mineka, Behavior Therapy for Specific Fears and Phobias: Context Specificity of Fear Extinction. Wilson, Manual-Based Treatment and Beyond. McCarthy, Bolt, Baker, The Importance of How: A Call for Mechanistic Research in Tobacco Dependence Treatment Studies. Part III: Model Integrative Research Programs. Lang, McTeague, Cuthbert, Fear, Anxiety, Depression, and the Anxiety Disorder Spectrum: A Psychophysiological Analysis. Townsend, Fific, Neufeld, Assessment of Mental Architecture in Clinical/Cognitive Research. Treat, Dirks, Bridging Clinical and Cognitive Science. Steinmetz, Using a Simple Associative Learning Procedure to Study Clinical Disorders and Related Brain Function. Part IV: Future Directions for Research, Application, and Training. Cuthbert, Psychological Clinical Science: The Next 20 Years. Levenson, The Future of the Clinical Science Movement: Challenges, Issues, and Opportunities. Part V: Closing Chapter. McFall, On Psychological Science.