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XIth International Symposium on Amyloidosis

Edited by Martha Skinner, John L. Berk, Lawreen H. Connors, David C. Seldin

Contributors: Ping Zhou, John O'Grady, Merrill D. Benson, Catherine E. Costello, Juris J. Liepnieks, Giampaolo Merlini, Knut Sletten, Alan Solomon, Nigel Heaton, Raymond L. Comenzo, Konen Obayashi, Toshiyuki Yamada, Helen J. Lachmann, Vaismali Sancnorawala, Brian O'Nullain, Yoshitaka Kumon, Shiori Saito, Jaemi Kim, Charles Murphy, Teresa Williams, Daniel Kestler, Jonathan S. Wall, Maria Rosario Almeida, Shmuel Shtrasburg, Jennifer Ellis Ward, Xiao Ying Fu, Sofia Nystrom, Limin Wang, Julie Teruya-Feldstein, Stefano Perlini, Heather Landau, Batia Kaplan, Adam D. Cohen, John Bela Ancsin, Arie Stangon, Shingo Himeno, Satoru Shinriki, Grace Monis, Xuyang Peng, Ruiyi Ren, Tale Norbye Wien, Ming Xu, James S. Foster, John Andrew Hunter, Stephen John Kennel, Maria M. Picken, Meran Lidar, Eiji O'Hara, Kiyoko Oshima, Tina Richey, Jana Sponarova, Akihiko Ueda, Manuel Zeledon Ramirez, Shuchung Wang, Mohammad Reza Ardalan, Curtis Barry, Brian Spencer, Jonathan S. Kingsbury, Elena Klimtchuk, Naoko Kakizoe, Sally D. Macy, Luis F. Acero, Amy Allen, Kip L. Bodi, Daniel Coriu, Manfred Eulitz, Jianmin Gan, Zhennng Hong, John Keeling, Jonathan Phipps, Asnutosn D. Wechalekar, Huihong Xu, Amanda Flies, Joan L. Berk, Craig Wooliver, Roger N. Picken, Takaaki Akaike, Ronglih Liao, Gloria R. Gallo, Bouke P.C. Hazenberg, Keiichi Higuchi, Ola Sandgren, Maurya Kaut, Tatiana Prokaeva, Mark Mccomb, Yukio Ando, Xuguo Sun, Mitsuharu Ueda, Takahiro Kawaji, Makoto Uchino, Lee Lomas, Masaaki Nakamura, Taro Yamashita, Deborah Weiss, Eiko Ando, Masaki Otagiri, Gregorio Valencia, Avi Livneh, Vickery Trinkaus-Randall, Fumi Varyani, May San Mak, Yoshihiro Motomiya, Yohei Misumi, Wei Meng, Umeko Semba, Hirohumi Kai, Sumiko Abe-Dohmae, Shinji Yokoyama, Tetsuro Sugiura, Douglas Sawyer, Derek Baxter, Pamela Soohoo, David Pimental, Cheng Lin, Roger Theberge, Yoshinori Uji, Hidenobu Tanihara, Ole B. Suhr, Yukihiro Inomata, Katsuhiro Asonuma, Sandra M. Davern, Junko Fujii, Marianna Budnik, Yan Jiang, Jeremy Eberhard, Sofia Z. Varady, Monica Dogaru, Dan Colita, Mirccea Manuc, Gabriel Becheanu, Raluca Bobeica, Emanuel Stoica, Crisanda Vilciu, Sorina Zamfir, Camelia Dobrea, Cezar Macarie, Alina D. Tanase, Camelia A. Ionescu, Mihai Voiculescu, Carl J. O'Hara, Amareth Lim, Peter O'Connor, Olga Gursky, Gheorghe Doros, Daniel A. Brenner, Thomas G. Christensen, David H. Sherr, Laura Obici, Tomoo Hirahara, Sadahisa Okamoto, Takaaki Ito, Masanori Shinohara, Yu Ishima, G.A. Hererra, J. Teng

CRC Press – 2007 – 432 pages

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    978-1-42-004281-8
    July 23rd 2007

Description

Edited by a stellar team of scientists compiling more than 120 papers into a single volume, the XIth Annual International Symposium on Amyloidosis represents the most important review of the state-of-the-science and future directions of this rapidly growing field. An unparalleled cast of pioneering researchers, including keynote speaker and Nobel Laureate Dr. Stanley Prusiner, present groundbreaking research in systemic amyloidosis including the mechanisms of disease and cellular toxicity, AA amyloidosis, familial amyloidosis, AL amyloidosis, clinical trials, and emerging Divided into six sections, the book begins with a study of the mechanisms of fibril formation and cellular response. It investigates possible horizontal transmission, charge differences of deposits in AL and NALCDD, and novel assays to detect amyloid induced apoptosis. The second section considers AA and localized amyloidosis and presents advances in non-invasive imaging, amyloid typing, and the translocation of systemic amyloidosis. The section on familial and TTR amyloidosis features an original report on hereditary gelsolin amyloidosis in an Iranian family, as well as other novel and rare mutations. An extensive section on AL amyloidosis introduces ALBASE as a platform analysis tool, AL amyloidosis in the elderly, and a study of the therapeutic potential of naturally occurring antibodies. Section five focuses on new and emerging diagnostic and translational approaches including characterization and identification through biopsy, mass spectrometry, proteomics, and the use of an amyloid "chip". The book concludes with clinical trials of diflunisal and high dose melphalan-dexamethasone and autologous stem cell transplantation.

translational approaches.

Focusing on new basic and translational medicine approaches in systemic amyloidosis, XIth Annual International Symposium on Amyloidosis provides clinicians and researchers with an invaluable single source reference to the most up-to-date research in the field.

Contents

Preface

Outstanding Achievement Award - Dr. Alan S. Cohen

Symposium Keynote Address - Dr. Stanley Prusiner

Report of the Nomenclature Committee

MECHANISMS OF FIBRIL FORMATION AND CELLULAR RESPONSE

KEYNOTE ADDRESS: The Effect of Membranes and Surfaces on the Fibrillation of an Amyloidogenic Light Chain: Relevance to the Etiology of Al Amyloidosis, X. Meng, M. Zhu, and A.L. Fink

Heparan Sulfate Promotes the Refolding and Oligomerization of SAA1.1: A Short Sequence is Implicated in this Misfolding Process, J.B. Ancsin, E. Elimova, and R. Kisilevsky

Mouse Senile Amyloidosis: Possible Horizontal Transmission in the Mouse Room, X. Fu, T. Korenaga, J. Yan, F. Ge, B. Zhang, J. Qian, H. Naiki, J. Sawashita, M. Mori, and K. Higuchi

Charge Differences of Deposits in AL and NALCDD, B. Kaplan, A. Livneh, and G. Gallo

Role of the C-terminal Amino Acids in ß2-Microglobulin Amyloid Formation, J. Kim, Y. Motomiya, M. Nakamura, M. Ueda, S. Saito, Y. Misumi, S. Himeno, K. Obayashi, S. Shinriki, W. Meng, U. Semba, H. Kai, and Y. Ando

Serum Amyloid A Generates High-Density Lipoprotein from Human Aortic Smooth Muscle Cells, Y. Kumon, S. Abe-Dohmae, S. Yokoyama, and T. Sugiura

Amyloid Light Chains Localize to Lysosomes and Cardiac Fibroblasts Show Reduced Mitochondrial Function, G. Monis, J. Eberhard, L.H. Connors, M. Skinner, and V. Trinkaus-Randall

Cerebrospinal Fluid and Plasma of Alzheimer Patients Promote ß-Amyloid Fibril Formation In Vitro, K. Ono, M. Noguchi-Shinohara, M. Samuraki, Y. Matsumoto, D. Yanase, K. Iwasa, H. Naiki, and M. Yamada

A Novel Assay for Detection of Amyloid Induced Apoptosis, J.F. Paulsson, S.W. Schultz, M. Köhler, I. Leibiger, P.-O. Berggren, and G.T. Westermark

Human Amyloidogenic Immunoglobulin Light Chains Alter Cardiomyocyte Signaling and Disrupt Heparan Sulfate Proteoglycan (HSPG) Expression, X. Peng, E. Kim, T. Miller, G. Karamitis, L.H. Connors, M. Skinner, and D.B. Sawyer

GAGs Associated with Fibril Extracts Mediate Fibrillogenesis in AL Amyloidosis, R. Ren, Z. Hong, L.H. Connors, M. Skinner, C.E. Costello, and V. Trinkaus-Randall

Decorin in AA Amyloidosis, T.N. Wien, R. Sørby, T. Landsverk, and G. Husby

Structural Evolution of Immunoglobulin Light Chain during Amyloid Fibril Formation: A Deep UV Resonance Raman Spectroscopic Study, M. Xu, E.M. Baden, K.M. Jasmin, M. Ramirez-Alvarado, and I.K. Lednev

AA AND LOCALIZED AMYLOIDOSES

KEYNOTE ADDRESS: AA Amyloidogenesis: Basic and Translational Research, R. Kisilevsky and W.A. Szarek

Histochemical and Immunohistochemical Characteristics of Amyloid Deposits, Á. Apáthy and M. Bély

Ultrastructural Characteristics of Amyloid Deposits, M. Bély, Á. Apáthy, and P. Kapp

Odontogenic Feline and Canine Tumor-Associated Amyloid is Formed from Ameloblastin, R. Donnell, C.L. Murphy, M. Eulitz, T.K. Williams, S.D. Macy, D.T. Weiss, and A. Solomon

Amyloidogenic Region of Odontogenic Ameloblast Associated Protein (ODAM), J.S. Foster, D.P. Kestler, C.L. Murphy, S.J. Kennel, J.S. Wall, D.T. Weiss, and A. Solomon

What is the Best Way to Assess Predisposition to AA Amyloid in Inflammatory Joint Disease?, J.A. Hunter, R.D. Baxter, A. Stirling, J. France, F. Varyani, and M.S. Mak

Advances in Non-Invasive Imaging of AA Amyloid in Mice, S.J. Kennel, T. Richey, J.S. Avenell, P.N. Hawkins, A. Solomon, and J.S. Wall

Detection and Identification of Amyloid Deposition Associated with Human Unerrupted Tooth Follicles, D.P. Kestler, J. Hudson, S.D. Macy, C.L. Murphy, J.S. Foster, D.T. Weiss, and

A. Solomon

Vascular AA Amyloid Formation Modeled in Cell Culture, B. Kluve-Beckerman

Amyloidosis in Ankylosing Spondylitis - Unexpected Findings Underscoring the Importance of Typing of Amyloid Deposits, D. Kracker, N.O. Litbarg, and M.M. Picken

Lack of Correlation Between Amyloid A Protein Levels and Clinical Parameters in Aspirated Fat Tissue of Familial Mediterranean Fever Patients with Secondary Amyloidosis, M. Lidar, B.P. Hazenberg, J. Bijzet, W. Hauck, D. Garceau, R. Kedem, and A. Livneh

Chronic, Slowly Progressing Nephropathy Due to Amyloidosis of CSAA (SAA4) Origin, R.P. Linke, S. Adler, U. Hegenbart, S. Schönland, J. Lutz, F.C. deBeer, and H.-J. Gröne

Redistribution, Clearance and Re-induction of Amyloid in Reactive Murine AA Amyloidosis, S.N. Nyström and G.T. Westermark

N-Formyl Peptide Receptor-Like 1 of the Neutrophils in the AA-Amyloidosis Tissues is Less Stained, E. Ohara, Y. Kumon, and T. Sugiura

AL in the Clinical Setting of AA: The Importance of Amyloid Typing, K. Oshima, D. Kracker, and M.M. Picken

Foie Gras is a Dietary Source of AEF, T. Richey, C.L. Murphy, J.S. Wall, G.T. Westermark, P. Westermark, D.T. Weiss, and A. Solomon

The Effect of a Variety of Anti-Inflammatory Drugs on Murine Amyloidogenesis, S. Shtrasburg, M. Lidar, M. Pras, R. Gal, and A. Livneh

Translocation of Systemic Amyloidosis by Peripheral Blood Monocytes, J. Sponarova, S.N. Nystrom, and G.W. Westermark

FK506 Inhibits Murine AA Amyloidosis Without Modulating Serum SAA Levels, M. Ueda, Y. Ando, M. Nakamura, T. Yamashita, K. Obayashi, Y. Misumi, S. Shinriki, A. Ueda, R. Zeledon, S. Himeno, S. Saito, J. Kim, W. Meng, and M. Uchino

Local Tumorous AA-Amyloid Deposition in a Case of Hepatic Adenomatosis: Immunohistochemistry and In Situ Hybridization Employing SAA-mRNA Probes, S. Urieli-Shoval, P. Flemming, M. Stolte, and R.P. Linke

SAA4-Related AA Amyloidosis, S. Wang, C.L. Murphy, D. Kestler, S.D. Macy, T.K. Williams, D.T. Weiss, and A. Solomon

Measurement of Amyloidogenic SAA Isotype, SAA1, T. Yamada, and Y. Okuda

FAMILIAL AND TTR AMYLOIDOSES

In Vitro and In Vivo Effects of Genistein on TTR Stabilization and Aggregation, M.R. Almeida, I. Cardoso, N. Ferreira, and M.J. Saraiva

Labial Salivary Gland Biopsy for Diagnosis of Amyloid Polyneuropathy Portuguese Type, B. Amaral, T. Coelho, and A. Guimarães

Hereditary Gelsolin Amyloidosis in an Iranian Family: The First Report from the Middle East, M.R. Ardalan, M.M. Shoja, T. Paunio, S. Tanskanen, S. Kiuru-Enari, A. Rastegar, and M. Kashgarian

A Case of Compound Heterozygosity in a Nigerian Male with Identification of a New Transthyretin Variant Phe44Leu and Val122Ile, C.T. Barry, T. Prokaeva, P. Soohoo, B. Spencer, D. Pimental, and L.H. Connors

Suppression of HepaticT synthesis by Antisense Oligonucleotides, M.D. Benson and B. Kluve-Beckerman

Top-Down Mass Spectrometry Analysis of Amyloidogenic Proteins, C.E. Costello, R. Théberge, C. Lin, J. Kingsbury, E. Klimtchuk, L.H. Connors, M. Skinner, D.C. Seldin, and P.B. O'Connor

ATTR (Thr59Lys) Amyloidosis with Involvement of Heart, Peripheral and Autonomic Nervous System, Gut and Salivary Glands in an Egyptian Man, Previously Diagnosed as "Familial Amyloid Neuropathy of Portuguese Type", G.E. Feurle, J.J. Liepnieks, M.D. Benson, and R.P. Linke

Systemic Amyloidosis of Fibrinogen Origin in the Wild Living Stone Marten (Martes Foina), O. Geisel, R. Mentele, F. Lottspeich, and R.P. Linke

Familial Amyloid Nephropathy of Fibrinogen Aa (E526V) Origin. Report of the First Case from Austria, S. Hargassner, G. Biesenbach, G. Syré, K. Altland, and R.P. Linke

Laryngeal Amyloidosis in Patients with Apolipoprotein AI I174S and I178P, A.J.C. Hazenberg, F.G. Dikkers, P.N. Hawkins, J. Bijzet, D. Rowczenio, M.D. Posthumus, M.K. Leijsma, J. van der Wal, and B.P.C. Hazenberg

Hereditary Fibrinogen A a-Chain Amyloidosis: Clinical Features and the Curative Role of Liver Transplantation, N.D. Heaton, J. O'Grady, M. Rela, P. Muiesan, J.A. Wendon, L. Sizer, J. Sedgwick, M. Thoma, F. Murgatroy, C.J. Mathias, H.J. Goodman, D. Rowczenio, A. Bybee, G. Tennent, P.N. Hawkins, and A.J. Stangou

Amyloidosis in the Transgenic Mice of Mouse Amyloidogenic Apolipoprotein A-II (apoa2c), K. Higuchi, F. Ge, X. Fu, J. Yao, Z. Guo, J. Yan, B. Zhang, H. Zhang, J. Qian, J. Sawashita, and M. Mori

Urinary Transthyretin: A Possible Biochemical Marker in the Early Stage of Renal Dysfunction, S. Himeno, M. Ueda, M. Nakamura, T. Yamashita, K. Obayashi, X. Sun, Y. Misumi,

S. Shinriki, A. Ueda, Y. Uji, S. Saito, J. Kim, W. Meng, and Y. Ando

Unique Phenotype of Vitreous Amyloidosis in Different Endemic Areas, N. Kakizoe, Y. Ando, T. Kawaji, E. Ando, O. Sandgren, O.B. Suhr, and H. Tanihara

Composition of Peripheral Nerve Amyloid after Orthotopic Liver Transplant for FAP, J.C. Kincaid, J.J. Liepnieks, and M.D. Benson

Characterization of Fibrillar Transthyretin in Ex Vivo Cardiac Deposits from Cases of Senile Systemic Amyloidosis, J.S. Kingsbury, R. Théberge, C.E. Costello, and L.H. Connors

Comparison of Cardiac Amyloidosis Associated with Wild Type Transthyretin and the Isoleucine 122 Variant, H.J. Lachmann, H.J.B. Goodman, J.D. Gillmore, A. Wechalekar, D.M. Rowczenio, A. Bybee, and P.N. Hawkins

AL Amyloidosis in a Patient with a T60A TTR Mutation, H.J. Landau, R.L. Comenzo, P. Zhou, B. Clark, J. Teruya-Feldstein, S. Wang, C.L. Murphy, and A. Solomon

Biochemical Characterization of Leptomeningeal Amyloid in a Val30Gly Transthyretin Patient, J.J. Liepnieks, S. Vakili, and M.D. Benson

Apolipoprotein A-I (apo A-I) Nature of Knee Joint Meniscus-Associated Amyloid, S.D. Macy, T.K. Williams, C. Wooliver, C.L. Murphy, S. Wang, D. Kestler, P. Westermark, D.T. Weiss, and A. Solomon

An Autopsy Case of Familial Amyloidotic Polyneuropathy ATTR Val30Met 10 Years After Liver Transplantation: Changes in the Amount of Amyloid Deposits in the Pancreas, Y. Misumi, Y. Ando, M. Nakamura, T. Yamashita, S. Himeno, M. Ueda, X. Obayashi, X. Sun, S. Saito, J. Kim, S. Shinrik, W. Meng, A. Ueda, and M. Uchino

Amyloid Neuropathy in a Japanese Domino Liver-Transplanted Recipient, K. Obayashi, T. Yamashita, M. Ueda, M. Nakamura, K. Asonuma, Y. Inomata, M. Uchino, K. Tanaka, and Y. Ando

The Natural History of Hereditary Apolipoprotein A-I Amyloidosis According to a Large Series of Italian Leu75Pro Patients, L. Obici, G. Gregorini, F. Scolari, l. Calabresi, T. Scalvini, S. Donadei, and G. Merlini

Domino Liver Transplantation Using the Explanted Grafts from Patients with Hereditary Forms of Amyloidosis: The King's College Hospital Experience, J. O'Grady, M. Rela, P. Muiesan, M. Bowles, R. Williams, P.N. Hawkins, N.D. Heaton, and A.J. Stangou

Cardiomyopathy in FAP Val30Met Patients With and Without Liver Transplantation, S. Okamoto, T. Yamashita, Y. Ando, and M. Uchino

Detection of Cardiac Pre-Amyloid Deposits of Transthyretin by MALDI-TOF, R.N. Picken, M. Morgan, and M.M. Picken

Effect of Nitric Oxide in Transthyretin-Related Amyloidosis, S. Saito, Y. Ando, M. Ueda, J. Kim, M. Nakamura, T. Yamashita, K. Obayashi, Y. Misumi, S. Shinriki, S. Himeno, W. Meng, Y. Ishima, T. Akaike, and M. Otagiri

Inhibition of Intracellular Tetramerization Induces the Proteasomal Degradation of Amyloidogenic Transthyretin Variants, T. Sato, S. Susuki, M. Miyata, Y. Ando, T. Shuto, M.A. Suico, and H. Kai

Structural Analyses of Fibrinogen Aa-Chain Amyloid Fibrils, L.C. Serpell, M.D. Benson, J.J. Liepnieks, and P.E. Fraser

A Transthyretin Mutation (V32A) in an Israeli Patient with Amyloidotic Neuropathy Localizes to a 3-D Mutation Cluster, Y. Shinar, B. Kaplan, C. Avisar, and A. Livneh

Amyloid Deposition in the Tongue of Patients with Familial Amyloidotic Polyneuropathy, S. Shinriki, M. Ueda, T. Yamashit, K. Obayashi, X. Sun, S. Himeno, A. Ueda, Y. Misumi, S. Saito, J. Kim, W. Meng, M. Shinohara, and Y. Ando

Recent Novel and Rare Mutations in a Clinic Population of Patients with Amyloidosis, B. Spencer, L.H. Connors, T. Prokaeva, P. Soohoo, C. O'Hara, and M. Skinner

Proliferation of Smooth Muscle Cells in the Tunica Intima of Cerebral Vessels in Familial Amyloidtic Polyneuropathy ATTR Y114C, A. Ueda, M. Ueda, T. Yamashita, T. Hirano, M. Nakamura, Y. Misumi, W. Meng, T. Ito, M. Uchino, and Y. Ando

Reengineering TTR Amyloid Inhibition Properties of Diflunisal, M. Vilaró, G. Arsequell, G. Valencia, A. Ballesteros, J. Barluenga, J. Nieto, A. Planas, R. Almeida, and M.J. Saraiva

Familial Amyloidosis Associated with a Novel Mutation (D68G) in the Lysozyme Gene, C. Wooliver, D. Coriu, C.L. Murphy, D.P. Kestler, S. Wang, D.T. Weiss, and A. Solomon

Effects of Liver Transplantation on Hereditary Cerebral Amyloid Angiopathy Associated with ATTR Y114C, T. Yamashita, Y. Ando, M. Ueda, M. Nakamura, S. Okamoto, T. Hirahara, A. Ueda, Y. Misumi, K. Obayashi, and M. Uchino

Effect of Tacrolimus and Cyclosporine on Transthyretin (TTR) Metabolism in Rats: A Long Term Analysis, R. Zeledon, Y. Ando, K. Asonuma, M. Nakamura, M. Ueda, X. Sun, J. Fujii, and Y. Inomata

AL AMYLOIDOSIS

KEYNOTE ADDRESS: Can AL Amyloidosis Be Cured?, D.C. Seldin

Identification of Novel Inhibitors of Light Chain Fibrillogenesis, L. Acero, A. Solomon, J.S. Wall, and B. O'Nuallain

Peptide Phage Display and Epitope Mapping of a Fibril-Related Conformational Epitope Recognized by the 11-1F4 Monoclonal Antibody, A. Allen, S.J. Kennel, A. Solomon, J.S. Wall, and B. O'Nuallain

The Translocation t(11;14) Is Frequently Detected in Patients with AL Amyloidosis, T. Bochtler, S.O. Schonland, F. Cremer, D. Hose, M. Moos, C. Bartram, A.D. Ho, H. Goldschmidt, A. Jauch, and U. Hegenbart

ALBASE: A Platform Analysis Tool for the Study of Amyloid Light Chain Sequence Data, K.L. Bodi, M. Kaut, B. Spencer, F. Lavatelli, C. Costello, L.H. Connors, M. Skinner, and D.C. Seldin

Risk-Adapted Melphalan with Stem Cell Transplant (SCT) and Adjuvant Dexamethasone (DEX) +/- Thalidomide (THAL) Achieves Low Treatment-Related Mortality and High Hematologic Response Rates, A.D. Cohen, P. Zhou, L. Reich, H. Hassoun, J. Teruya-Feldstein, D.A. Filippa, B. Clark, M. Stubblefield, M. Fleisher, S.D. Nimer, and R.L. Comenzo

A Supervised Analysis of Gene-Expression Profiles of Purified Clonal Plasma Cells From Patients with Systemic Light-Chain Amyloidosis (AL) Who Have High or Low Levels of Serum Free Lambda Light Chains, R.L. Comenzo, P. Zhou, M. Fleisher, and A.B. Olshen

Comparison of Immunoglobulin Light Chains (?1): Amyloidogenic vs. Non-Amyloidogenic Proteins, L.H. Connors, J. Eberhard, B. Spencer, T. Prokaeva, Y. Jiang Y, M. Budnik, R. Théberge, D.C. Seldin, C.E. Costello, and M. Skinner

Clinicopathological Analysis of Thirty-Two Patients with AL Amyloidosis: Four-Years Experience in a Single Institution, D. Coriu, C. Dobrea, M.Dogaru, S. Zamfir, E. Stoica, C. Macarie, M. Voiculescu, C. Ionescu, R. Bobeica, C. Valciu, G. Becheanu, M. Manuc, A.Tanase, S.Varady, and D. Colita

Role of Light Chain Deamidation in the Pathogenesis of AL Amyloidosis, M. Eulitz, C.L. Murphy, D.T. Weiss, and A. Solomon

The Extent and Distribution of Amyloid in 38 Autopsies on Patients with Primary (AL) Amyloidosis, J. Gan, L.H. Connors, M. Skinner, and C.J. O'Hara

Transplantation without Growth Factor Engraftment Kinetics Following Stem Cell Transplantation for Primary Systemic Amyloidosis, M.A. Gertz, M Q. Lacy, A. Dispenzieri, S.R. Hayman, S.K. Kumar, and D. Gastineau

Extent of Hematologic Response is Important in Determining Outcome in Transplanted Patients with Primary Systemic Amyloidosis. Importance of Achieving a Complete Response, S.R. Hayman, M.Q. Lacy, A. Dispenzieri, S.K. Kumar, D.A. Gastineau, and M.A. Gertz

A Single-Center Experience Using Chemotherapy with Melphalan-Dexamethasone (M-dex) in Patients with AL Amyloidosis and Advanced Organ Involvement Not Eligible for High-Dose Melphalan Therapy (HDM), U. Hegenbart, T. Bochtler, J.B. Dengler, M. Hundemer, A.D. Ho, H. Goldschmidt, and S.O. Schonland

Detection and Characterization of AL Light Chain Proteins from Fibrils, Z. Hong, R. Théberge, A. Lim, T. Prokaeva, L.H. Connors, M. Skinner, and C.E. Costello

Characterization of Post-Translational Modifications of an Amyloidogenic Immunoglobulin Kappa Light Chain by Mass Spectrometry, Y. Jiang, R. Thebérge, J. Eberhard, G. Karamitis, T. Prokaeva, L.H. Connors, M. Skinner, C. Lin, P.B. O'Connor, and C.E. Costello

Involvement of Lysosomes in Renal AL-Amyloidogenesis, J. Keeling, and G.A. Herrera

Thermal Unfolding of Immunoglobulin Light Chains is Linked to Aggregation: Circular Dichroism and Light Scattering Studies, E.S. Klimtchuk, O. Gursky, J. Eberhard, L.H. Connors, and M. Skinner

Prognostic Relevance of Serum N-Terminal Pronatriuretic Peptide Type B and Plasma BNP in Patients with AL Amyloidosis in Dialysis, M. Nuvolone, G. Palladini, F. Lavatelli, P. Russo, V. Perfetti, S. Perlini, L. Obici, F. Clari, and G. Merlini

AL Amyloidosis in the Elderly: A Review of 330 Patients, M. Offer, A.D. Wechalekar, H.J. Lachmann, J.D. Gillmore, and P.N. Hawkins

Therapeutic Potential of Naturally Occurring Fibril-Reactive Human Antibodies for AL Amyloidosis, B. O'Nuallain, A. Allen, T. Richey, J.S. Wall, D.T. Weiss, and A. Solomon

Prolonged Follow-Up Study of AL Patients Ineligible for Stem Cell Transplantation Treated with Oral Melphalan and Dexamethasone, G. Palladini, F. Lavatelli, P. Russo, M. Nuvolone, V. Perfetti, L. Obici, and G. Merlini

Left Ventricular Systolic Function in Patients with Cardiac AL Amyloidosis, S. Perlini, M. Vezzoli, F. Clari, G. Palladini, P. Russo, M. Nuvolone, and G. Merlini

In Vitro Silencing of Amyloidogenic ?6 Light Chain Production, J.E. Phipps, J.S. Foster, D.P. Kestler, A. Solomon, and J.S. Wall

Amyloid Typing in Surgical Pathology: Experience of a Single Institution, M.M. Picken

Somatic Mutations Create Potential N-Glycosylation Sites in the Immunoglobulin Light Chain Variable Regions in Primary Amyloidosis, T. Prokaeva, B. Spencer, G. Doros, K. Bodi, J. Eberhard, Y. Jiang, M. Budnik, R. Théberge, C.E. Costello, L.H. Connors, M. Skinner, and D.C. Seldin

A Trial of Antioxidants to Improve Cardiac Function in Patient with AL Amyloidosis and Cardiac Involvement, M. Rosenzweig, D. Sawyer, F. Ruberg, D. Wright, V. Sanchorawala, D. Seldin, J. Vita, R. Lala, D. Brenner, F. Sam, and M. Skinner

High-Dose Melphalan Chemotherapy with Autologous Stem Cell Transplantation in 65 Patients with AL Amyloidosis: Organ Progression Can Be Delayed in Patients Reaching Complete Remission, S.O. Schonland, J.B. Dengler, M. Hundemer, T. Bochtler, R. Singer, E. Hund, J. Beimler, M. Zeier, A.V. Kristen, T.J. Dengler, A.D. Ho, H. Goldschmidt, and

U. Hegenbart

Glycosylated Amyloid and Non-Amyloid Associated Lambda Light Chains, K. Sletten, S. Wang, C.L. Murphy, F.J. Stevens, D.T. Weiss, and A. Solomon

Extramedullary Production of AL Amyloid Precursor Protein, A. Solomon, D.T. Weiss, S.D. Macy, C. Wooliver, and P. Westermark

Mesangial Amyloid Formation in an Isolated Rat Kidney Perfusion Model: A New Model to Study Renal Amyloidogenesis, J. Teng and G.A. Herrera

Overexpression of Calreticulin in Clonal Al Plasma Cells is Associated with Response to Melphalan and Autologous Stem Cell Transplant in Systemic Light-Chain (AL) Amyloidosis, J. Teruya-Feldstein, P. Zhou, A.B. Olshen, and R.L. Comenzo

Semi-Quantitative Assessment of Amyloid in Congo Red-Stained Subcutaneous Abdominal Fat Tissue in Systemic Amyloidosis and Disease Severity, I.I. van Gameren, B.P.C. Hazenberg, J. Bijzet, E. Brouwer, M.D. Posthumus, and M.H. van Rijswijk

Imaging Human AL Amyloid in Mice Using the Fibril-Reactive Monoclonal Antibody 11-1F4, J.S. Wall, S.J. Kennel, T. Richey, J.S. Avenell, and A. Solomon

Tandem Mass Spectrometry and Other Methods Identify Apolipoprotein E3 and Kappa 1 Light Chain in Amyloid Fibrils Extracted from a Patient with AL Amyloidosis, L. Wang, X. Yuan, B. Clark, N. Lampen, H. Deng, Y. Zhang, and R.L. Comenzo

Mouse Models of AL Amyloidosis, J.E. Ward, D. Brenner, P. Soohoo, L. Cui, R. Liao, X. Peng, D. Sawyer, L.H. Connors, T. Christensen, C. O'Hara, M. Skinner, and D.C. Seldin

NT-ProBNP in AL Amyloidosis: Association with Survival and Changes After Chemotherapy, A. Wechalekar, H. Lachmann, J. Gillmore, M. Offer, J. Joshi, and P. Hawkins

Histochemical-Based Staging System for AL Amyloidosis, D.T. Weiss, C. Wooliver, and A. Solomon

Localized AL Amyloidosis: A Distinctive Clinicopathologic Disorder, T.K. Williams, S.D. Macy, C. Wooliver, C.L. Murphy, P. Gorevic, P. Westermark, D.T. Weiss, and A. Solomon

Evaluation of Plasma Cell Volume and Clonality in AL (primary) Amyloidosis by Analysis of Pre and Post Stem Cell Transplantation Bone Marrow Core Biopsies (BMCB), H. Xu, P. Soohoo, G. Doros, M. Skinner, and C. O'Hara

Biochemical Characterization of Amyloid from a Rectal Amyloidoma, Z. Zaky, O. Cummings, J.J. Liepnieks, D. Rex, and M.D. Benson

NEW DIAGNOSTICS AND EMERGING TRANSLATIONAL APPROACHES

KEYNOTE ADDRESS: Advances in Systemic Amyloidoses: From Mechanisms to Better Care, G. Merlini

The Diagnosis of Amyloidosis May Be Hindered by the Sampling Error, and How to Prevent It, M. Bandmann and R.P. Linke

Serum Amyloid P Component (SAP) Concentration in Abdominal Fat Aspirates of Patients with Amyloidosis, J. Bijzet, B.P.C. Hazenberg, P.N. Hawkins, M.K. Leijsma, E. Brouwer, M.D. Posthumus, and M.H. van Rijswijk

Biochemical Characterization of Amyloid by Endomyocardial Biopsy, J. Breall, M.D. Benson, J.J. Liepnieks, and O. Cummings

A Peptide-Based Vaccine Elicits CTL Responses towards AL Amyloid-Related Immunoglobulin Light Chain, A. Flies and D.H. Sherr

Diagnostic Accuracy and Prognostic Value of 123I-Labeled Serum Amyloid P Component Body Retention in Patients with Amyloidosis, B.P.C. Hazenberg, M.N. Lub-de Hooge, E. Vellenga, E.B. Haagsma, M.D. Posthumus, and P.L. Jager

A Proteomic Approach to the Study of Systemic Amyloidoses, F. Lavatelli, D.H. Perlman, B. Spencer, T. Prokaeva, M.E. McComb, R. Théberge, L.H. Connors, V. Bellotti, D.C. Seldin, G. Merlini, M. Skinner, and C.E. Costello

Definitive Identification of Amyloid Deposits by Mass Spectrometry, C.L. Murphy, S. Wang, T.K. Williams, D.T. Weiss, and A. Solomon

Tissue Detection of Amyloid by an Amyloid "Chip"?, M.M. Picken, B.P.C. Hazenberg, and L. Lomas

Detection and Characterization of Immunoglobulin Light Chain Post-Translational Modifications Using LC/MS-MS/MS, R. Théberge, Y. Jiang, M.E. McComb, T. Prokaeva, L.H. Connors, M. Skinner, D.C. Seldin, and C.E. Costello

The Inhibitory Fc?-Receptor IIB (CD32B) Is Highly Expressed on Clonal Plasma Cells from Patients with Systemic Light-Chain (AL) Amyloidosis and Provides a Target for Monoclonal Antibody Therapy, P. Zhou, A.B. Olshen, E. Bonvini, S. Koenig, M. Fleisher, J. Young, A. Boruchov, and R.L. Comenzo

CLINICAL SESSIONS

DIAGNOSTIC INTERACTIVE SESSION: Report, M.M. Picken, B.P.C. Hazenberg, and L. Obici

CLINICAL INTERACTIVE SESSION: Report, V. Sanchorawala, G. Palladini, and A. Dispenzieri

CLINICAL TRIAL REPORTS: Clinical Trial for TTR Amyloidosis Using Diflunisal, J.L. Berk, A.B. Bisbee, J.W. Kelly, P.J. Dyck, R.H. Falk, Y. Ando, T. Coelho, S. Ikeda, G. Merlini, O.B. Suhr, M. Skinner, and the Diflunisal Investigators Consortium

Early Harvest Followed by Melphalan-Dexamethasone and Second-Line Autologous Stem Cell Transplantation in AL, P. Russo, G. Palladini, V. Perfetti, F. Lavatelli, M. Nuvolone, L. Obici, and G. Merlini

Treatment of AL Amyloidosis with Tandem Cycles of High Dose Melphalan and Autologous Stem Cell Transplantation: Final Analysis of a Prospective Trial , V. Sanchorawala, D.G. Wright, K. Quillen, K.T. Finn, L.M. Dember, J.L. Berk, G. Doros, C. Fisher, M. Skinner, and D.C. Seldin

Name: XIth International Symposium on Amyloidosis (Hardback)CRC Press 
Description: Edited by Martha Skinner, John L. Berk, Lawreen H. Connors, David C. SeldinContributors: Ping Zhou, John O'Grady, Merrill D. Benson, Catherine E. Costello, Juris J. Liepnieks, Giampaolo Merlini, Knut Sletten, Alan Solomon, Nigel Heaton, Raymond L. Comenzo, Konen Obayashi, Toshiyuki Yamada, Helen J. Lachmann, Vaismali Sancnorawala, Brian O'Nullain, Yoshitaka Kumon, Shiori Saito, Jaemi Kim, Charles Murphy, Teresa Williams, Daniel Kestler, Jonathan S. Wall, Maria Rosario Almeida, Shmuel Shtrasburg, Jennifer Ellis Ward, Xiao Ying Fu, Sofia Nystrom, Limin Wang, Julie Teruya-Feldstein, Stefano Perlini, Heather Landau, Batia Kaplan, Adam D. Cohen, John Bela Ancsin, Arie Stangon, Shingo Himeno, Satoru Shinriki, Grace Monis, Xuyang Peng, Ruiyi Ren, Tale Norbye Wien, Ming Xu, James S. Foster, John Andrew Hunter, Stephen John Kennel, Maria M. Picken, Meran Lidar, Eiji O'Hara, Kiyoko Oshima, Tina Richey, Jana Sponarova, Akihiko Ueda, Manuel Zeledon Ramirez, Shuchung Wang, Mohammad Reza Ardalan, Curtis Barry, Brian Spencer, Jonathan S. Kingsbury, Elena Klimtchuk, Naoko Kakizoe, Sally D. Macy, Luis F. Acero, Amy Allen, Kip L. Bodi, Daniel Coriu, Manfred Eulitz, Jianmin Gan, Zhennng Hong, John Keeling, Jonathan Phipps, Asnutosn D. Wechalekar, Huihong Xu, Amanda Flies, Joan L. Berk, Craig Wooliver, Roger N. Picken, Takaaki Akaike, Ronglih Liao, Gloria R. Gallo, Bouke P.C. Hazenberg, Keiichi Higuchi, Ola Sandgren, Maurya Kaut, Tatiana Prokaeva, Mark Mccomb, Yukio Ando, Xuguo Sun, Mitsuharu Ueda, Takahiro Kawaji, Makoto Uchino, Lee Lomas, Masaaki Nakamura, Taro Yamashita, Deborah Weiss, Eiko Ando, Masaki Otagiri, Gregorio Valencia, Avi Livneh, Vickery Trinkaus-Randall, Fumi Varyani, May San Mak, Yoshihiro Motomiya, Yohei Misumi, Wei Meng, Umeko Semba, Hirohumi Kai, Sumiko Abe-Dohmae, Shinji Yokoyama, Tetsuro Sugiura, Douglas Sawyer, Derek Baxter, Pamela Soohoo, David Pimental, Cheng Lin, Roger Theberge, Yoshinori Uji, Hidenobu Tanihara, Ole B. Suhr, Yukihiro Inomata, Katsuhiro Asonuma, Sandra M. Davern, Junko Fujii, Marianna Budnik, Yan Jiang, Jeremy Eberhard, Sofia Z. Varady, Monica Dogaru, Dan Colita, Mirccea Manuc, Gabriel Becheanu, Raluca Bobeica, Emanuel Stoica, Crisanda Vilciu, Sorina Zamfir, Camelia Dobrea, Cezar Macarie, Alina D. Tanase, Camelia A. Ionescu, Mihai Voiculescu, Carl J. O'Hara, Amareth Lim, Peter O'Connor, Olga Gursky, Gheorghe Doros, Daniel A. Brenner, Thomas G. Christensen, David H. Sherr, Laura Obici, Tomoo Hirahara, Sadahisa Okamoto, Takaaki Ito, Masanori Shinohara, Yu Ishima, G.A. Hererra, J. Teng. Edited by a stellar team of scientists compiling more than 120 papers into a single volume, the XIth Annual International Symposium on Amyloidosis represents the most important review of the state-of-the-science and future directions of this rapidly...
Categories: Neurology, Neuroscience, Pathology