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The Laboratory Mouse, Second Edition

By Peggy J. Danneman, Mark A. Suckow, Cory Brayton

CRC Press – 2012 – 256 pages

Series: Laboratory Animal Pocket Reference

Purchasing Options:

  • Add to CartPaperback: $59.95
    978-1-43-985421-1
    September 25th 2012

Description

Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse.

Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse.

Reviews

"This latest in-color edition includes new discussions on disease prevention and testing, transportation, and phenotyping… Overall, this book is well-written and highly applicable to today’s laboratory animal care and use programs … Like the first edition, it is a ‘must have’ for any reference library."

—Robin Crisler-Roberts, DVM, MS, DACLAM, Indiana University School of Medicine, Indianapolis, USA

Contents

Important Biological Features

Introduction

Stocks and Strains

Nomenclature

Behavior

Anatomic and Physiologic Features

Normative Values

Hematology

Immunodeficient Mice

Wild Mice

References

Husbandry

Housing

Barriers and Containment

Personal Protective Equipment (PPE)

Special Considerations for Immunodeficient Mice

Environment

Sanitation and Pest Control

Nutrition

Water

Breeding

Identification and Record Keeping

Transportation

References

Management

Regulatory Agencies and Compliance

Institutional Animal Care and Use Committee (IACUC)

Occupational Health and Zoonotic Diseases

References

Clinical Medicine

Basic Veterinary Supplies

Physical Examination of the Mouse

Common Spontaneous and Noninfectious Diseases

Common Infectious Diseases

Treatment and Supportive Care of Sick Mice

Clinical Endpoints

Treating Disease on a Colony Basis

References

Preventive Medicine

Receiving

Testing of Biological Materials

Health Surveillance and Monitoring

Disease Prevention through Sanitation

References

Experimental Methodology

Restraint

Sampling Methods

Compound Administration

Phenotyping

Anesthesia and Analgesia

Euthanasia

Necropsy

References

Resources and Additional Information

Organizations

Publications

Electronic Resources

Appendix A: Glossary of Phenotyping Terminology and Tests

Appendix B: Suggested Cassette Numbering System and Some Trimming Suggestions

Index

Author Bio

Peggy J. Danneman is a Senior Director of Laboratory Animal Health Services at The Jackson Laboratory in Bar Harbor, Maine. Mark A. Suekow is the Director of the Freimann Life Sciences Center at the University of Notre Dame, Indiana. Cory Brayton is the Director of Phenotyping Core for Johns Hopkins Medicine, Maryland.

Name: The Laboratory Mouse, Second Edition (Paperback)CRC Press 
Description: By Peggy J. Danneman, Mark A. Suckow, Cory Brayton. Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of...
Categories: Laboratory Animal Science, Toxicology, Neuroscience