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Introduction to Natural Products Chemistry

Edited by Rensheng Xu, Yang Ye, Weimin Zhao

CRC Press – 2011 – 381 pages

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    978-1-43-986076-2
    July 19th 2011

Description

Natural products chemistry—the chemistry of metabolite products of plants, animals and microorganisms—is involved in the investigation of biological phenomena ranging from drug mechanisms to gametophytes and receptors and drug metabolism in the human body to protein and enzyme chemistry.

Introduction to Natural Products Chemistry has collected the most important research results of natural product chemistry in China. It overviews the basic principles of isolation, structure, and characteristics of natural products and illustrates current research techniques of structure elucidation with real-life examples of wet chemistry and spectroscopic analyses (UV, IR, MS, and NMR, especially 2d-NMR, HMBC, and HMQC), bioactivity, biosynthesis, and chemical synthesis.

Specifically, this book covers:

  • Extraction and isolation of natural products
  • Chemistry of fungal products
  • Alkaloids, sesquiterpenoids, diterpenes, and saponins
  • Amino acids and peptides
  • Flavonoids, anthraquinones, coumarins, and lignans
  • Marine natural products
  • Structural modification of active principles from traditional Chinese medicine
  • Chemical synthesis of natural products

Although natural products chemistry has produced enormous results and made great contributions to human health, industry, and agriculture, only a fraction of natural resources have been rigorously studied. Chinese natural products are a gold mine for further exploration with modern technology and methods. This book represents the continuing collaboration between the fields of natural products chemistry, medicine, biology, and agriculture which will continue to discover and implement novel chemical products from natural sources.

Contents

Introduction, Ren-Sheng Xu

Extraction and Isolation of Natural Products. Ren-Sheng Xu

Extraction of Natural Products

Separation of Natural Products

Concluding Remarks

Bibliography

References

Chemistry of Fungal Products, Zhi-Hong Xu

Introduction

Bioactive Fungal Metabolites

Mycotoxins from Fungi

Isolation and Structure Studies of Fungal Products

Perspectives

References

Alkaloids, Ren-Sheng Xu and Yang Ye

General

Characterization, Identification and Isolation

Classification

Structural Investigations of Some Alkaloids

Bibliography

References

Sesquiterpenoids, Zhong-Liang Chen

Chemical Properties, Isolation and Purification

Spectroscopic Analysis of Sesquiterpenes

Artemisinin - Chemistry, Pharmacology, and Clinical Uses

Recent Progress of Specific Sesquiterpenes

References

Diterpenes, Zhi-DaMin

Main Diterpene Skeletons

Biogenesis

Labdanes

Clerodanes

Pimaranes

Abietanes

Cassanes and Totaranes

Taxanes

Tiglianes, Ingenanes and Daphnanes

Jatrophanes and Lathyranes

Myrsinols and Euphorsctines

Ginkgolides and Pseudolaric Acid

References

Saponins, Wei-Min Zhao

Introduction

Extraction and Isolation of Saponins

Structure Determination of Saponins

Biological Activity of Saponins

Triterpenoid Saponin

Steroidal Saponins

Bibliography

References

Amino Acids and Peptides, Chang-Qi Hu and Jie-Cheng Xu

Amino Acids

Peptides

References

Flavonoids, De-Yun Kong

Overview

Extraction and Isolation of Flavonoids

Identification and Structure Study of Flavonoids

Pharmacological Study of Flavonoids

Flavonoids Assay Determination and Formulation

Conclusion

References

Anthraquinones, Yang Lu

Introduction

Physical and Chemical Properties

Extraction and Isolation

Spectral Characteristics

Examples

References

Coumarins, Ze-Nai Chen

Introduction

Structural Types

Physical and Chemical Properties

Isolation

Spectroscopic Identification

Research Example

References

Lignans, Chang-Qi Hu

Introduction

Structural Types and Characteristics of Lignans

Bioactivities of Lignans

References

Other Natural Bioactive Compounds, Ren-Seng Xu

Sulfur Compounds

Cyanide Compounds

Coixenolide

Resveratrol

Muscone

Cardiac Glycosides

Bibliography

References

Marine Natural Products, Yue-Wei Guo and Wen Zhang

Introduction

Marine Plants

Marine Invertebrates

Marine Microorganisms and Phytoplankton

Miscellaneous

Examples

Epilogue (Outlook)

References

Structural Modification of Active Principles from TCM, Da-Yuan Zhu

Introduction

Anti-malaria Drug Arthemether

Anti-hepatitis Drug Bifendate

Anti-AD Drug Huperzine A

Antiarrhythmia Drug Changrolin

Antineoplastic Drugs

Computer-Aided Drug Design

References

Chemical Synthesis of Natural Products, Wen-Hu Duan

Alkaloids

Terpene

Flavonoids

Synthesis of Anthraquinones

Lignans

Synthesis of Macrolide Antibiotics

Bibliography

References

Name: Introduction to Natural Products Chemistry (Hardback)CRC Press 
Description: Edited by Rensheng Xu, Yang Ye, Weimin Zhao. Natural products chemistry—the chemistry of metabolite products of plants, animals and microorganisms—is involved in the investigation of biological phenomena ranging from drug mechanisms to gametophytes and receptors and drug...
Categories: Botany, Pharmacology, Natural Products