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Applied Meta-Analysis with R

By Ding-Geng (Din) Chen, Karl E. Peace

Chapman and Hall/CRC – 2013 – 342 pages

Series: Chapman & Hall/CRC Biostatistics Series

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    May 3rd 2013


In biostatistical research and courses, practitioners and students often lack a thorough understanding of how to apply statistical methods to synthesize biomedical and clinical trial data. Filling this knowledge gap, Applied Meta-Analysis with R shows how to implement statistical meta-analysis methods to real data using R.

Drawing on their extensive research and teaching experiences, the authors provide detailed, step-by-step explanations of the implementation of meta-analysis methods using R. Each chapter gives examples of real studies compiled from the literature. After presenting the data and necessary background for understanding the applications, various methods for analyzing meta-data are introduced. The authors then develop analysis code using the appropriate R packages and functions. This systematic approach helps readers thoroughly understand the analysis methods and R implementation, enabling them to use R and the methods to analyze their own meta-data.

Suitable as a graduate-level text for a meta-data analysis course, the book is also a valuable reference for practitioners and biostatisticians (even those with little or no experience in using R) in public health, medical research, governmental agencies, and the pharmaceutical industry.


Introduction to R

What Is R?

Steps on Installing R and Updating R Packages

Database Management and Data Manipulations

A Simple Simulation on Multi-Center Studies

Summary and Recommendations for Further Reading

Research Protocol for Meta-Analyses


Defining the Research Objective

Criteria for Identifying Studies to Include in the Meta-Analysis

Searching For and Collecting the Studies

Data Abstraction and Extraction

Meta-Analysis Methods


Summary and Discussion

Fixed Effects and Random Effects in Meta-Analysis

Two Datasets from Clinical Studies

Fixed-Effects and Random-Effects Models in Meta-Analysis

Data Analysis in R

Which Model Should We Use? Fixed Effects or Random Effects?

Summary and Conclusions

Meta-Analysis with Binary Data

Meta-Analysis Methods

Meta-Analysis of Lamotrigine Studies


Meta-Analysis for Continuous Data

Two Published Datasets

Methods for Continuous Data

Meta-Analysis of Tubeless versus Standard Percutaneous Nephrolithotomy


Heterogeneity in Meta-Analysis

Heterogeneity Quantity Q and the Test of heterogeneity in R meta

The Quantifying Heterogeneity in R meta

Step-By-Step Implementations in R





Data Analysis Using R


Individual Patient-Level Data Analysis versus Meta-Analysis


Treatment Comparison for Changes in HAMD

Treatment Comparison for Changes in MADRS


Simulation Study on Continuous Outcomes


Meta-Analysis for Rare Events

The Rosiglitazone Meta-Analysis

Step-by-Step Data Analysis in R


Other R Packages for Meta-Analysis

Combining p-Values in Meta-Analysis

R Packages for Meta-Analysis of Correlation Coefficients

Multivariate Meta-Analysis



Author Bio

Ding-Geng (Din) Chen, Ph.D., is a professor at the University of Rochester Medical Center. Dr. Chen has vast experience in biostatistical research and clinical trial development and methodology. He has authored or co-authored more than 100 journal publications on biostatistical methodologies and applications. He is also the co-author (with Dr. Peace) of Clinical Trial Methodology and Clinical Trial Data Analysis Using R and a co-editor (with Drs. Sun and Peace) of Interval-Censored Time-to-Event Data: Methods and Applications. He is a member of the American Statistical Association, chair for the STAT section of the American Public Health Association, an associate editor of the Journal of Statistical Computation and Simulation, and an editorial board member of several other journals.

Karl E. Peace, Ph.D., is the Georgia Cancer Coalition Distinguished Cancer Scholar, senior research scientist, and professor of biostatistics in the Jiann-Ping Hsu College of Public Health at Georgia Southern University. He is also an adjunct professor of biostatistics at the VCU School of Medicine. Dr. Peace is a reviewer or editor of several journals, the founding editor of the Journal of Biopharmaceutical Statistics, and a fellow of the American Statistical Association. He has authored or co-authored over 150 articles and 10 books. He has received numerous awards, including the University System of Georgia Board of Regents’ Alumni Hall of Fame Award, the First President’s Medal for outstanding contributions to Georgia Southern University, and distinguished meritorious service awards from the American Public Health Association and other organizations. In 2012, the American Statistical Association created the Karl E. Peace Award for Outstanding Statistical Contributions for the Betterment of Society.

Name: Applied Meta-Analysis with R (Hardback)Chapman and Hall/CRC 
Description: By Ding-Geng (Din) Chen, Karl E. Peace. In biostatistical research and courses, practitioners and students often lack a thorough understanding of how to apply statistical methods to synthesize biomedical and clinical trial data. Filling this knowledge gap, Applied Meta-Analysis with R shows...
Categories: Statistical Theory & Methods, Clinical Trials - Pharmaceutical Science, Statistical Computing