Natural Products Chemistry
Sources, Separations and Structures
CRC Press – 2014 – 206 pages
Notoriously cumbersome to isolate and challenging to synthesize, the path of natural products to viable drugs is an arduous journey. Yet compounds isolated from nature have long been known to possessfascinating structures, biological profiles and pharmaceutical potential far greater than anything made by man. Natural Products Chemistry: Sources, Separations and Structures presents a practical guide to sourcing, isolating, and discovering new compounds from nature many of which become pharmaceutical drugs. This book emphasizes the challenges and advantages of products acquired from nature, compared to those obtained from combinatorial chemistry.
A basic introduction, the book describes the whole cycle from farm to final compound, backed up by case studies drawn from industry and research applications. It broadens the scope of applications and draws upon examples from various sources. Natural products chemistry, as taught today, draws its examples mainly from marine chemistry or plant chemistry; however, there is also a fascinating and rich world of fermented (microbial and algal) products leading to complex structures. Thus, the book draws upon examples from the microbial world and from insects too. Therefore, this is a source of bioactive metabolites, not traditionally available in academic settings, more the mainstay of the pharmaceutical industry.
Providing a roadmap of the process of collecting a compound from nature, isolating the active ingredient, and determining the chemical structure, this book provides a unique approach to the world of natural products.
History of Natural Products
Biological and Pharmacological Aspects
Fractionation and Isolation
Optimization for Mass Production and Manufacturing
Integrating with System Biology
Curation and Digitization
Licensing and Strategy
Drs. Cooper and Nicola were introduced to each other by CRC Press editor Hilary Rowe during a natural products conference. Inspired to pursue his passion for natural products by his former high school chemistry teacher, Dr. Cooper credits his longevity in the field to the great people and teams he has had the good fortune and privilege of working with. He says that one of the most rewarding aspects of his work has been the satisfaction that comes from being part of a team that is able to bring new products of natural product origin to market.