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Brain Diseases and Metalloproteins

Edited by David R. Brown

Pan Stanford Publishing – 2012 – 300 pages

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  • Add to CartHardback: $179.95
    9789814316019
    August 6th 2012

Description

This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson’s disease, Alzheimer’s disease, prion disease, and ALS. The chapters separately examine such issues as mechanisms of metal binding, metal-induced structural changes in proteins, alterations in cellular metal metabolism in disease, and attempts at a therapeutic approach based on protein metal binding.

Reviews

"This is an authoritative and thorough overview of a field of growing significance to neuroscience. Metal ion metabolism is intimately involved with the causes of most neurodegenerative disease, and is an area of unexploited importance for potential drug development. This work is timely, and tremendously useful with an excellent choice of subjects, beautifully and rigorously presented"

—Prof. Ashley I. Bush - University of Melbourne, Australia

Contents

Introduction David R. Brown

Brain Diseases

Metalloproteins

A Possible Key Role for Redox-Active Metal Ions and Soluble Oligomers in Neurodegenerative Disease Brian J. Tabner, Susan Moore, Jennifer Mayes, and David Allsop

Summary

Introduction to the Proteopathies

Mutations in Genes Associated with Protein Processing and Aggregation Cause Inherited Forms of Proteopathy

The Toxic Eff ects of Protein Oligomers

The Generation of Hydrogen Peroxide by Aβ Other Aggregating Protein Systems Mechanism of Hydrogen Peroxide Formation and Aβ Oxidation Concluding Comments Modelling of the Metal Binding Sites in Proteins Involved in Neurodegeneration Ewa Gralka, Daniela Valensin, Maurizio Remelli, and Henryk Kozlowski

Introduction

Peptides as Models for Unstructured Protein Interactions with Metal Ions

Structural Approach to Metal-Peptide Interactions (Role of His as the Metal Ion Binding Site)

Thermodynamic and Speciation Studies

Impact of Metal Ions on Prion Protein Fibril Formation

Impact of Metal-Peptide Interaction on Oxidative Stress

Mammalian Metallothioneins Duncan E. K. Sutherland and Martin J. Stillman

Metallothionein

Techniques for Studying Metallothioneins

MT-1 and MT-2: Inducible Metallothioneins

MT-3: A Central Nervous System Metallothionein

Copper Transporting P-Type ATPases in the Brain Sharon La Fontaine, James Camakaris, and Julian Mercer

ATP7A in the Brain

ATP7B in the Brain

Conclusion

Role of the Amyloid Precursor Protein and Copper in Alzheimer’s Disease Loredana Spoerri, Kevin J. Barnham, Gerd Multhaup and Roberto Cappai

The Amyloid Precursor Protein

Copper Physiology

Copper and Alzheimer’s Disease

APP, Copper and Alzheimer’s Disease

APP Copper Binding Domain (CuBD)

Conclusions

Role of Aluminum and Other Metal Ions in the Pathogenesis of Alzheimer’s Disease Silvia Bolognin and Paolo Zatta

Alzheimer’s Disease The Amyloid Cascade and Oligomer Hypothesis Metal Dysmetabolism in AD The Role of Metal Ions in the Aggregation and Toxicity of Aβ Aβ and Cell Membranes Amyloid Metal Complexes and Ca Conclusion

Prion Diseases, Metals and Antioxidants Paul Davies and David R. Brown

The Transmissible Spongiform Encephalopathies

The Prion Protein

PrP and Copper Binding

The Implications of Copper Binding

Other Metals

Metals and Aggregation

Changes in Brain Metals

PrP Survival in the Environment

Conclusion

Emerging Role for Copper-Bound α-Synuclein in Parkinson’s Disease Etiology Heather R. Lucas and Jennifer C. Lee

Introduction

Interaction of Copper(II) and α-Synuclein Metal-Catalysed Protein Oxidation Conclusion

Interactions of α-Synuclein with Metal Ions: New Insights into the Structural Biology and Bioinorganic Chemistry of Parkinson’s Disease Andrés Binolfi and Claudio O. Fernández

Introduction

Interaction of AS with Cu(II) Ions

Interaction of AS with Other Divalent Metal Ions

Structural Details Behind the Specificity of AS-Cu(II) Interactions

Conclusions and Future Perspectives

An Attempt to Treat Amyotrophic Lateral Sclerosis by Intracellular Copper Modification Using Ammonium Tetrathiomolybdate and/or Metallothionein: Fundamentals and Perspective 367 Shin-Ichi Ono, Ei-Ichi Tokuda, Eriko Okawa, and Shunsuke Watanabe

Introduction

Causes of ALS

Characterization of G93A Mutant SOD1 Mouse

Metallothionein, Copper Ions and ALS

Cellular Damage by Copper Overload

Therapeutic Strategy in Mutant SOD1 Mice Based on "Intracellular Cu Dysregulation" Hypothesis: Intracellular Copper Removal Using Ammonium Tetrathiomolybdate

Therapeutic Strategy in Mutant SOD1 Mice Based on "Intracellular Cu Dysregulation" Hypothesis: Intracellular Copper Modification Using a Metallothionein-I Isoform

Conclusion

Index

Name: Brain Diseases and Metalloproteins (Hardback)Pan Stanford Publishing 
Description: Edited by David R. Brown. This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson’s disease, Alzheimer’s...
Categories: Neurosurgery, Medicinal & Pharmaceutical Chemistry, Infectious Diseases