In biopharmaceutical statistics, simulation plays an indispensable role. Statisticians conduct simulation studies to thoroughly characterize different statistical methodologies and to compare their performance in terms of type I error, power, sample sizes, etc. This book offers programming codes (...
To Be Published December 26th 2015 by CRC Press
A Practical Guide with R
All the Essentials to Start Using Adaptive Designs in No Time Compared to traditional clinical trial designs, adaptive designs often lead to increased success rates in drug development at reduced costs and time. Introductory Adaptive Trial Designs: A Practical Guide with R motivates newcomers to...
To Be Published July 1st 2015 by Chapman and Hall/CRC
Get Up to Speed on Many Types of Adaptive Designs Since the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second...
Published December 1st 2014 by Chapman and Hall/CRC
Principles of Scientific Methods focuses on the fundamental principles behind scientific methods. The book refers to "science" in a broad sense, including natural science, physics, mathematics, statistics, social science, political science, and engineering science. A principle is often abstract and...
Published July 22nd 2014 by Chapman and Hall/CRC
The Future of Clinical Research and Health Care: From Empirical to Precision MedicineClinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators,...
Published March 27th 2014 by Chapman and Hall/CRC
Paradoxes are poems of science and philosophy that collectively allow us to address broad multidisciplinary issues within a microcosm. A true paradox is a source of creativity and a concise expression that delivers a profound idea and provokes a wild and endless imagination. The study of paradoxes...
Published October 15th 2012 by Chapman and Hall/CRC
With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA’s recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and...
Published December 1st 2011 by Chapman and Hall/CRC
Concepts, Algorithms, and Case Studies
Helping you become a creative, logical thinker and skillful "simulator," Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies provides broad coverage of the entire drug development process, from drug discovery to preclinical and clinical trial aspects to...
Published September 29th 2010 by CRC Press
Human Locomotion and Surface Factors
In recent decades, injury has begun to gain prominence as a public health and societal problem. Slipperiness and slip, trip, and fall (STF) injuries are among the greatest obstacles to reducing the injury burden. One of the biggest challenges in STF is defining and measuring slipperiness. After...
Published December 19th 2002 by CRC Press