Paradoxes are poems of science and philosophy that collectively allow us to address broad multidisciplinary issues within a microcosm. A true paradox is a source of creativity and a concise expression that delivers a profound idea and provokes a wild and endless imagination. The study of paradoxes...
Published October 14th 2012 by Chapman and Hall/CRC
With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA’s recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and...
Published November 30th 2011 by Chapman and Hall/CRC
Although adaptive design methods are flexible and useful in clinical research, little or no regulatory guidelines are available. One of the first books on the topic, Adaptive Design Methods in Clinical Trials presents the principles and methodologies in adaptive design and analysis that pertain to...
Published December 11th 2010 by Chapman and Hall/CRC
Concepts, Algorithms, and Case Studies
Helping you become a creative, logical thinker and skillful "simulator," Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies provides broad coverage of the entire drug development process, from drug discovery to preclinical and clinical trial aspects to...
Published September 28th 2010 by CRC Press
Adaptive design has become an important tool in modern pharmaceutical research and development. Compared to a classic trial design with static features, an adaptive design allows for the modification of the characteristics of ongoing trials based on cumulative information. Adaptive designs increase...
Published June 26th 2007 by Chapman and Hall/CRC
Human Locomotion and Surface Factors
In recent decades, injury has begun to gain prominence as a public health and societal problem. Slipperiness and slip, trip, and fall (STF) injuries are among the greatest obstacles to reducing the injury burden. One of the biggest challenges in STF is defining and measuring slipperiness. After...
Published December 18th 2002 by CRC Press