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1-10 of 11 results for Author: mark chang (sorted by Publication Date, showing all)

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  1. Introductory Adaptive Trial Designs

    A Practical Guide with R

    By Mark Chang

    Series: Chapman & Hall/CRC Biostatistics Series

    Instead of providing black box-like general commercial software packages, this tutorial-style book develops the R functions and algorithms necessary to customize adaptive designs to meet their needs. Designed as a practical, tutorial style resource, the book provides a 30 minute R tutorial and...

    To Be Published June 14th 2015 by Chapman and Hall/CRC

  2. Clinical Trial Simulations

    By Sandeep M. Menon, Mark Chang, Joseph M.W. Wu

    Series: Chapman & Hall/CRC Biostatistics Series

    In biopharmaceutical statistics, simulation plays an indispensable role. Statisticians conduct simulation studies to thoroughly characterize different statistical methodologies and to compare their performance in terms of type I error, power, sample sizes, etc. This book offers programming codes (...

    To Be Published May 24th 2015 by CRC Press

  3. Adaptive Design Theory and Implementation Using SAS and R, Second Edition

    By Mark Chang

    Series: Chapman & Hall/CRC Biostatistics Series

    Reflecting the state of the art in adaptive design approaches, Adaptive Design Theory and Implementation Using SAS and R provides a concise, unified presentation of adaptive design theories, uses SAS and R for the design and simulation of adaptive trials, and illustrates how to master different...

    To Be Published November 24th 2014 by Chapman and Hall/CRC

  4. Principles of Scientific Methods

    By Mark Chang

    Principles of Scientific Methods focuses on the fundamental principles behind scientific methods. The book refers to "science" in a broad sense, including natural science, physics, mathematics, statistics, social science, political science, and engineering science. A principle is often abstract and...

    Published July 21st 2014 by Chapman and Hall/CRC

  5. Clinical and Statistical Considerations in Personalized Medicine

    Edited by Claudio Carini, Sandeep M Menon, Mark Chang

    Series: Chapman & Hall/CRC Biostatistics Series

    The Future of Clinical Research and Health Care: From Empirical to Precision MedicineClinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators,...

    Published March 26th 2014 by Chapman and Hall/CRC

  6. Paradoxes in Scientific Inference

    By Mark Chang

    Paradoxes are poems of science and philosophy that collectively allow us to address broad multidisciplinary issues within a microcosm. A true paradox is a source of creativity and a concise expression that delivers a profound idea and provokes a wild and endless imagination. The study of paradoxes...

    Published October 14th 2012 by Chapman and Hall/CRC

  7. Adaptive Design Methods in Clinical Trials, Second Edition

    By Shein-Chung Chow, Mark Chang

    Series: Chapman & Hall/CRC Biostatistics Series

    With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA’s recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and...

    Published November 30th 2011 by Chapman and Hall/CRC

  8. Monte Carlo Simulation for the Pharmaceutical Industry

    Concepts, Algorithms, and Case Studies

    By Mark Chang

    Series: Chapman & Hall/CRC Biostatistics Series

    Helping you become a creative, logical thinker and skillful "simulator," Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies provides broad coverage of the entire drug development process, from drug discovery to preclinical and clinical trial aspects to...

    Published September 28th 2010 by CRC Press

  9. Adaptive Design Theory and Implementation Using SAS and R

    By Mark Chang

    Series: Chapman & Hall/CRC Biostatistics Series

    Adaptive design has become an important tool in modern pharmaceutical research and development. Compared to a classic trial design with static features, an adaptive design allows for the modification of the characteristics of ongoing trials based on cumulative information. Adaptive designs increase...

    Published June 26th 2007 by Chapman and Hall/CRC

  10. Adaptive Design Methods in Clinical Trials

    By Shein-Chung Chow, Mark Chang

    Series: Chapman & Hall/CRC Biostatistics Series

    Although adaptive design methods are flexible and useful in clinical research, little or no regulatory guidelines are available. One of the first books on the topic, Adaptive Design Methods in Clinical Trials presents the principles and methodologies in adaptive design and analysis that pertain to...

    Published November 15th 2006 by Chapman and Hall/CRC

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